Effect on capillary permeability in rabbits of Acalypha langinia Buddleia scordioides, Hylocereus undatus, Tecoma stans and Astianthus viminalis

Aqueous extracts of Acalypha langinia, Buddleia scordioides, Hylocereus undatus, Tecoma stans showed protective activity against the increased (both chloroform and histamine) skin vascular permeability in rabbits. The protective effect, measured as the reduction in leakage of Evans blue, were 90.2, 37.3, 43.5 and 69.3% respectively a dose of 250 mg/kg. Astianthus viminalis, showed only a 12.6% inhibition at the same dose. The results showed that the extracts produced a significant inhibitory effect on the capillary permeability in rabbit skin. Comparison was made between the action of the aqueous extracts and a known protective microvascular drug as troxerutin (25 mg/kg).